compound introduction
Azido-PEG4-Val-Cit-PAB-MMAE 是抗体偶联活性分子的一部分 (drug-linker conjugate for ADC)。由多肽 linker 和抗有丝分裂剂 MMAE (一种 tubulin 抑制剂) 连接而成。Azido-PEG4-Val-Cit-PAB-MMAE 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。 Azido-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains an azido-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.
