Tubastatin A盐酸盐是HDAC6选择性抑制剂,IC50为15 nM,比对其它亚型的抑制性高1000倍(相对HDAC8是57倍)。An HDAC6 inhibitor Tubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). An HDAC6 inhibitor
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Tubastatin A HCl
CAS number:1310693-92-5 molecular formula:C20H21N3O2.HCl
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Specs
| Chinese alias | Tubastatin A 盐酸盐 | ||
| English alias | BCP02887 | 4-((2-Methyl-3,4-dihydro-1H-pyrido(4,3-b)indol-5-yl)methyl)benzenecarbohydroxamic acid hydrochloride | N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride | TSA HCl | UNII-UHCM2AYJVX | CCG-268318 | SW219 | ||
| CAS number | 1310693-92-5 | molecular formula | C20H21N3O2.HCl |
| molecular weight | 371.86 g/mol | Exact mass | ≥98% |
| PSA | 57.500 Ų | logp | - |
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