DL-threo-PPMP是一种神经酰胺类似物，也是葡萄糖神经酰胺合酶的抑制剂。当以20µM的浓度使用时，它在MDCK细胞匀浆、小鼠肝微粒体和小鼠脑匀浆中分别抑制葡萄糖神经酰胺合酶70%、41%和62%。DL-threo-PPMP还抑制感染恶性疟原虫的红细胞中的鞘磷脂合酶活性，并抑制恶性疟原虫晚期环期生长（IC50=0.85µM）。它降低了HEK293细胞中Akt和核糖体蛋白S6的磷酸化，并增加了原代小鼠神经元的自噬通量。 DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin synthase activity in erythrocytes infected with P. falciparum and inhibits late ring-stage P. falciparum growth (IC50 = 0.85 µM). It reduces Akt and ribosomal protein S6 phosphorylation in HEK293 cells and increases autophagy flux in primary mouse neurons.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
DL-threo-PPMP (hydrochloride)
CAS number：139974-41-7 molecular formula：C29H50N2O3·HCl
overview
compound introduction
Specs
| Chinese alias | N-[(1R,2R)-1-羟基-3-吗啉-4-基-1-基丙烷-苯基-2-基]六癸酰胺盐酸盐 | DL-苏式-1-苯基-2-棕榈酰氨基-3-吗啉-1-丙醇 盐酸盐 | ||
| English alias | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol | rel-N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride | ||
| CAS number | 139974-41-7 | molecular formula | C29H50N2O3·HCl |
| molecular weight | 511.19 g/mol | Exact mass | - |
| PSA | 61.800 Ų | logp | 7.400 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
