compound introduction
A54556A是分离自链霉菌的不寻常的二肽，具有三烯酮侧链。它对革兰氏阳性和革兰氏阴性细菌（包括MRSA）有效。A54556A是最近重新发现的酰基肽肽（ADEP）抗生素的原始先导结构，其通过激活和失活Clp家族蛋白发挥作用。ADEP被认为是开发新一代抗药性抗生素的重要线索。 A54556A is an unusual depsipeptide isolated from|Streptomyces|sp., featuring a trienone side chain. It is potently active against Gram positive and Gram negative bacteria, including MRSA. A54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
