compound introduction
VP 14637抑制人呼吸道合胞病毒（HRSV），这是一种主要的呼吸道病毒病原体，在所有年龄段以及广泛的患者群体中均引起中度至重度上呼吸道和下呼吸道感染。VP-14637通过结合到F蛋白内核中的小疏水腔中（与HR1和HR2域同时相互作用）来抑制呼吸道合胞病毒融合。 VP 14637 inhibits human respiratory syncytial virus (HRSV) a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient populations. VP-14637 inhibits respiratory syncytial virus fusion by binding into a small hydrophobic cavity in the inner core of F protein, interacting simultaneously with both the HR1 and HR2 domains.
