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Platencin

CAS number:869898-86-2    molecular formula:C24H27NO6

overview

compound introduction

平板素是一种抗生素,它是平板霉素的更有效类似物,两者均最初源自| Streptomyces platensis |。机理研究表明,这两种化合物均可抑制细菌脂肪酸的生物合成,这对于细菌的生存至关重要。相对于仅影响FabF的平板霉素,平板素会影响两种对平板霉素抗性细菌有效的蛋白,因为它会影响β-酮酰基-ACP合酶II(FabF)和III(FabH)这两种必需蛋白。 Platencin is an antibiotic that is a more potent analogue of Platensimycin , both of which were originally derived from|Streptomyces platensis|. Mechanistic studies show that both compounds inhibit bacterial fatty acid biosynthesis, which is essential for the survival of bacteria. Platencin may have the potential to be more effective on Platensimycin resistant bacteria, because it affects two essential proteins, β-ketoacyl-ACP synthase II (FabF) and III (FabH), as opposed to Platensymycin, which affects only FabF.

Specs

Chinese alias-
English alias2,4-dihydroxy-3-({3-[(4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid | BDBM50601421 | 3-((3-((2S,4aS,8S,8aR)-1,3,4,7,8,8a-Hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphth
CAS number869898-86-2molecular formulaC24H27NO6
molecular weight425.47 g/molExact mass≥99%
PSA124.000 Ųlogp3.500

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