Information ML318 is a biaryl nitrile inhibitor of PvdQ acylase with IC50 of 20 nM for binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions.
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ML318
CAS number:1610516-67-0 molecular formula:C14H8F4N2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1610516-67-0 | molecular formula | C14H8F4N2 |
| molecular weight | 280.22 g/mol | Exact mass | ≥98% |
| PSA | 36.700 Ų | logp | 3.300 |
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