赖氨酸是一种具有质子化烷基氨基的碱性生酮氨基酸。赖氨酸的降解会导致乙酰乙酸酯的形成。组蛋白中赖氨酸残基的乙酰化/去乙酰化是调节真核生物中染色质组织的机制。同位素标记的氨基酸是产生同位素标记的蛋白质所必需的。 应用 脉冲稳定同位素标记可用于研究HIV-1感染的人类单核细胞衍生巨噬细胞中蛋白质合成的宿主细胞功能、存活，以及精确细胞内途径。L-赖氨酸-13C6，15N2盐酸盐已用于pSILAC（细胞培养中氨基酸的脉冲稳定同位素标记）质谱法，以研究microRNA转染后细胞中的蛋白质谱。它已被用于SILAC同位素标记中，以表征赖氨酸消旋酶。它已用于SILAC标记，在经和未经GFKP-19（2-吡咯烷酮衍生物）处理的神经-2a细胞中进行磷酸化蛋白质组学的测定。 Lysine is a basic ketogenic amino acid with a protonated alkyl amino group. Lysine degradation results in the formation of acetoacetate. Acetylation/deacetylation of lysine residues in histones is a mechanism to regulate chromatin organization in eukaryotes. Isotope labeled amino acids are required for the production of isotopically labeled proteins.Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages.L-Lysine-13C6,15N2hydrochloride has been used in pSILAC (pulsed stable isotope labeling by amino acids in cell culture) mass spectrometry to study protein profile in cells transfected with microRNAs.It has been used in SILAC isotopic labeling for the characterization of lysine racemase.It has been used in SILAC labeling for phosphoproteomic measurements in neuro-2a cells treated with and without GFKP-19 (2-pyrrolidone derivative).
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L-Lysine-¹³C₆,¹⁵N₂ hydrochloride
CAS number：1200447-00-2 molecular formula：¹³C6H14¹⁵N2O2•(HCl)
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Specs
| Chinese alias | - | ||
| English alias | ¹³C and ¹⁵N Labeled Lys, SILAC Amino Acid, (S)-2,6-Diaminohexanoic acid-¹³C₆,¹⁵N₂ hydrochloride, ¹³C and ¹⁵N Labeled lysine hydrochloride | ||
| CAS number | 1200447-00-2 | molecular formula | ¹³C6H14¹⁵N2O2•(HCl) |
| molecular weight | 154.133646 g/mol | Exact mass | ≥99 atom% 15N,≥99 at |
| PSA | - | logp | - |
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1200447-00-2 | L-LYSINE-13C6,15N2 HYDROCHLORIDE,.pdf
