compound introduction
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC 50 value of 7 nM for hu mGluR7 . CVN636 has central nervous system (CNS) permeability In Vivo CVN636 (0.3-3 mg/kg; p.o.) reduces ethanol self-administration in msP rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: msP rat Dosage: 0.3, 1, and 3 mg/kg Administration: oral administration Result: Reduced alcohol self-administration in a dose-dependent. IC50& Target:hu mGluR7 7 nM (EC 50 )
