Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre Appearance:Solid IC50& Target:NF-κB Amyloid-β (Aβ) α4β2 nAChR In Vitro:Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hou In Vivo:Anatabine (0.5-2mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease. MCE has not independently confirmed th Biological Activity:Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre
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Anatabine dicitrate
CAS number：unknown molecular formula：C22H28N2O14
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| Chinese alias | 柠檬酸阿那他滨 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H28N2O14 |
| molecular weight | 544.46 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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