CAS number：287196-91-2 molecular formula：C11H6F3N3OS
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 是骨形态发生蛋白 2 (BMP2) 的抑制剂，IC50为 2.2 μM。3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 是丝裂原活化蛋白激酶 1 (MEK1) 的抑制剂。3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 在 EAE 小鼠模型中表现出抗炎和神经保护活性。
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| CAS number | 287196-91-2 | molecular formula | C11H6F3N3OS |
| molecular weight | 285.25 g/mol | Exact mass | ≥99% |
| PSA | 90.200 Ų | logp | 3.000 |
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