CAS number：872511-34-7 molecular formula：C26H31Cl2N7O3
BGJ398 (NVP-BGJ398)是一种有效的，选择性的FGFR抑制剂，作用于FGFR1/2/3，IC50为0.9 nM/1.4 nM/1 nM，作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上，对Abl， Fyn， Kit， Lck， Lyn和Yes几乎没有抑制活性。Phase 2。 BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4.
| Chinese alias | - | ||
| English alias | BGJ398 (NVP-BGJ398) | 872511-34-7 (free base) | AKOS000295891 | WHO 10032 | 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea | BCP0726000187 | DB11886 | Infigratinib | Q27075200 | SCHEMBL374435 | ||
| CAS number | 872511-34-7 | molecular formula | C26H31Cl2N7O3 |
| molecular weight | 560.48 g/mol | Exact mass | - |
| PSA | 95.100 Ų | logp | 4.7 |
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