compound introduction
XL019 是一种有效的、口服活性的、选择性的 JAK2 抑制剂，对 JAK2，JAK1，JAK3 的 IC50 分别为 2.2、134.3、214.2 nM。XL019 对JAK2的选择性是 100 多种丝氨酸/苏氨酸和酪氨酸激酶（包括 JAK 家族的其他成员）的 50 倍或更高。XL019 对 JAK2 V617F 和野生型 JAK2 细胞中 STAT3 和 STAT5 磷酸化的抑制作用。
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XL019
CAS number：945755-56-6 molecular formula：C25H28N6O2
overview
Specs
| Chinese alias | - | ||
| English alias | SCHEMBL4382715 | Lycoran-1.alpha., 3,3a-didehydro- | 4L1AM42NVA | MFCD24386874 | A859333 | SW219757-1 | 3,6,9,12,15,18,21,24-Octaoxahexacosan-1-ol, 26-(nonylphenoxy)- | GTPL7971 | OXOTHIAZOLIDINECARBOXYLIC ACID [INCI] | NCGC00381563-04 | VMB75556 | HY-137 | ||
| CAS number | 945755-56-6 | molecular formula | C25H28N6O2 |
| molecular weight | 444.53 g/mol | Exact mass | - |
| PSA | 91.400 Ų | logp | 2.800 |
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