CAS number：1005775-56-3 molecular formula：C21H21N5O.2HCl
TC ASK 10 (Compound 10) 是一种有效的，选择性的，口服活性的细胞凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50 为 14 nM。TC ASK 10 对其他代表性激酶的抑制活性低于 50％，ASK2 除外 (IC50 为 0.51 μM)。 TC ASK 10 is a potent ASK1 inhibitor. It displays selectivity for ASK1 over other kinases including ASK2, MEKK1, TAK1, IKKb, ERK1, JNK1, p38a, GSK-3b, PKC╬╕ and B-raf. It blocks downstream JNK1/p38 phosphorylation in cells.
| Chinese alias | 4-(1,1-二甲基乙基)-N-[6-(1H-咪唑-1-基)咪唑并[1,2-a]吡啶-2-基]苯甲酰胺二盐酸盐 | ||
| English alias | 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride | N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride | ||
| CAS number | 1005775-56-3 | molecular formula | C21H21N5O.2HCl |
| molecular weight | 432.35 g/mol | Exact mass | ≥98% |
| PSA | 64.200 Ų | logp | - |
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