compound introduction
Rhosin hydrochloride 是一种有效的，特异性的 RhoA 亚家族 Rho GTPases 抑制剂，能特异性的结合 RhoA，抑制 RhoA-GEF 相互作用，Kd 值 ~ 0.4 uM，但不与 Cdc42 或 Rac1，GEF，LARG 相互作用。Rhosin hydrochloride 可诱导细胞凋亡。Rhosin hydrochloride 通过增强 D1 中棘神经元的可塑性和降低过度兴奋性来促进应激恢复。
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Rhosin hydrochloride
CAS number：1281870-42-5 molecular formula：C20H19ClN6O
overview
Specs
| Chinese alias | D-色氨酸(2E)-2-(6-喹喔啉基亚甲基)酰肼盐酸盐 | 盐酸松香 | ||
| English alias | D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride | (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride | G04 hydrochloride | Rhosin HCl | ||
| CAS number | 1281870-42-5 | molecular formula | C20H19ClN6O |
| molecular weight | 394.86 g/mol | Exact mass | 10mM in DMSO |
| PSA | 109.000 Ų | logp | - |
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