compound introduction
NVP 231 是一种强效、特异、可逆的神经酰胺激酶 (CerK) 抑制剂 (IC50=12 nM)，可竞争性地抑制神经酰胺与 CerK 的结合。NVP 231 通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡 (apoptosis)。
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NVP-231
CAS number：362003-83-6 molecular formula：C25H25N3O2S
overview
Specs
| Chinese alias | - | ||
| English alias | AS-73454 | N-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide | s6501 | SR-01000456438 | N-[2-(benzoylamino)-6-benzothiazolyl]-Tricyclo[3.3.1.13,7]decane-1-carboxamide | N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxam | ||
| CAS number | 362003-83-6 | molecular formula | C25H25N3O2S |
| molecular weight | 431.55 g/mol | Exact mass | - |
| PSA | 99.300 Ų | logp | 5.300 |
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