compound introduction
Eg5抑制剂V，trans-24是可透过细胞的HR22C16衍生物，对有丝分裂驱动蛋白Eg5-ATPase活性具有增强的效价（对于trans-24和HR22C16，IC | 50 | = 0.65 vs. 4.3 µM），几乎没有或没有针对其他9种驱动蛋白的活性。显示可诱导HeLa细胞（20 µM）的单星形表型。 Eg5 Inhibitor V, trans-24 is a cell-permeable HR22C16 derivative that exhibits much enhanced potency against mitotic kinesin Eg5-ATPase activity (IC|50|= 0.65 vs. 4.3 μM for trans-24 and HR22C16, respectively) and little or no activity against 9 other kinesins. Shown to induce monoastral phenotype in HeLa cells (20 μM).
