PD-L1-IN-1 是一种有效的 PD-L1 抑制剂，IC50 为 115 nM。PD-L1-IN-1与PD-L1蛋白强结合，并在表达 PD-L1 的癌细胞（PC9 和 HCC827 细胞）和外周血单核细胞的共同培养中激发 PD-L1 蛋白，增强后者的抗肿瘤免疫活性。PD-L1-IN-1 显著增加了干扰素 γ 的释放和癌细胞的凋亡诱导，对健康细胞的细胞毒性较低。 应用： 聚合物共混物和液体分散体中的添加剂，用于电磁屏蔽、电荷耗散、电极、电池和传感器。聚苯胺可用于线性致动器。1银纳米颗粒（AgNPs）、氧化石墨烯（GO）、氧化铝（α-Al2O3）、碳纤维和石墨等各种纳米材料，可以与PANI一起用于开发转化医学、 超级电容器、 摩擦电纳米发电机 和其他储能应用。 PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells.
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Polyaniline (emeraldine salt)
CAS number：2767424-13-3 molecular formula：
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| Chinese alias | 聚苯胺 | ||
| English alias | PANI | ||
| CAS number | 2767424-13-3 | molecular formula | |
| molecular weight | - | Exact mass | 平均Mw＞15000,粉末(不熔),粒径 |
| PSA | - | logp | - |
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