CAS number：2105904-82-1 molecular formula：C20H24ClFN4O9P2
AB-680 是一种选择性可逆的CD73(胞外核苷酸酶) 抑制剂，具有抗肿瘤活性。它对 hCD73 的Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。 AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.
| Chinese alias | AB-680 | ||
| English alias | UNII-J6K8WSV73A | [[(2~{R},3~{S},4~{R},5~{R})-5-[6-chloranyl-4-[[(1~{S})-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | [[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2- | ||
| CAS number | 2105904-82-1 | molecular formula | C20H24ClFN4O9P2 |
| molecular weight | 580.82 g/mol | Exact mass | - |
| PSA | 196.000 Ų | logp | -0.700 |
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