ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes ( STING ). In Vitro ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:STING
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ADU-S100 disodium salt
CAS number：1638750-95-4 molecular formula：C20H22N10Na2O10P2S2
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| Chinese alias | ADU-S100二钠盐 | ||
| English alias | ADU S100 [WHO-DD] | ADENOSINE, (P(R))-5'-O-((R)-HYDROXYMERCAPTOPHOSPHINYL)-P-THIOADENYLYL-(2'->5')-, CYCLIC NUCLEOTIDE, SODIUM SALT (1:2) | Cdn agonist adu-S100 | A936364 | disodium;(1R,6R,8R,9R,10S,15R,17R,18R)-8,17-bis(6-aminopurin-9-yl)-3,12-dioxido-3, | ||
| CAS number | 1638750-95-4 | molecular formula | C20H22N10Na2O10P2S2 |
| molecular weight | 734.51 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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