Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 ( mTLR4/MD-2 ) agonist with an EC 50 of 18.5 μM. In Vitro Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC 50 of 18.5 μM. Neoseptin-3 induces TNFα production by macrophages in a concentration-dependent manner. Neoseptin-3 induces phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also increase in response to Neoseptin-3. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TLR4 18.5 μM (EC 50 )
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Neoseptin 3
CAS number：1622863-21-1 molecular formula：C29H34N2O4
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| Chinese alias | 新塞普汀 3 | ||
| English alias | - | ||
| CAS number | 1622863-21-1 | molecular formula | C29H34N2O4 |
| molecular weight | 474.59 g/mol | Exact mass | ≥99% |
| PSA | 102.000 Ų | logp | 5.600 |
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