FAPI-4 is a potent fibroblast activation protein ( FAP ) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68 Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer , with good tumor-to-background contrast ratios In Vivo FAPI-4 (Intravenous injection; 30 nmol per mouse; once) shows excellent tumor uptake in BALB/c nu / nu mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-week-old BALB/c nu / nu mice inoculated with HT-1080-FAP cellsDosage: 30 nmol per mouse Administration: Intravenous injection; 30 nmol per mouse; once Result: Revealed the high overall tumor uptake (9.44%ID/g 4 h after injection). Form:Solid IC50& Target:Fibroblast activation protein (FAP)
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FAPI-4
CAS number：2374782-02-0 molecular formula：C40H54F2N10O10
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| Chinese alias | 联邦航空管理局 | ||
| English alias | MS-31619 | FAPI-04 | FAPI-4 | ICWDAESAANBIGG-LJAQVGFWSA-N | AT39479 | DOTA-fapi-04 | EX-A5967 | 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl | ||
| CAS number | 2374782-02-0 | molecular formula | C40H54F2N10O10 |
| molecular weight | 872.91 g/mol | Exact mass | ≥98% |
| PSA | 244.000 Ų | logp | -6.800 |
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