STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC 50 and pIC 50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer. In Vitro STING agonist-3 exhibits a pEC 50 value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter. ? STING agonist-3 exhibits a pIC 50 value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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STING agonist-3
CAS number：2138299-29-1 molecular formula：C37H42N12O6
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| Chinese alias | STING 激动剂-3 | ||
| English alias | - | ||
| CAS number | 2138299-29-1 | molecular formula | C37H42N12O6 |
| molecular weight | 750.81 g/mol | Exact mass | ≥99% |
| PSA | 245.000 Ų | logp | 1.600 |
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