(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy. Appearance:Solid In Vitro:(D)-PPA 1 TFA (0.2 mg/mL, 1.0 mg/mL) blocks the interaction between PD-1/PD-L1 at 1.0 mg/mL. (D)-PPA 1 TFA (3.125-100 μM; 24 h, 48 h) doesn’t kill tumor cells directly with no affect on CT26 cells growth. MCE has not independently confirmed the In Vivo:(D)-PPA 1 TFA (2mg/kg; s.c. or i.p.; once daily for 7 d) inhibits CT26 tumor growth in vivo in mice. (D)-PPA 1 TFA (40 μg/mouse in 200 μL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice. MCE has not inde Biological Activity:(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy.
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(D)-PPA 1 TFA
CAS number：unknown molecular formula：C72H99F3N20O23
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| Chinese alias | (D)-对苯二甲酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C72H99F3N20O23 |
| molecular weight | 1669.67 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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