BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1 , with an IC 50 of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation In Vitro BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC 50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.4 nM (PD-1/PD-L1 interaction)
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BMS-1166 hydrochloride
CAS number：2113650-05-6 molecular formula：C36H34Cl2N2O7
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| Chinese alias | BMS-1166 盐酸盐 | ||
| English alias | - | ||
| CAS number | 2113650-05-6 | molecular formula | C36H34Cl2N2O7 |
| molecular weight | 677.57 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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