Senicapoc(ICA17043)是Gardos通道阻断剂,能抑制钙离子诱导的人血红细胞(RBC)铷流,IC50为11 nM,还能抑制血红细胞(RBC)的脱水,IC50为30 nM. Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.
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Senicapoc
CAS number:289656-45-7 molecular formula:C20H15F2NO
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Specs
| Chinese alias | 塞尼卡泊 | ||
| English alias | 2,2-bis(4-fluorophenyl)-2-phenylacetamide | A904983 | BBL102413 | DB06280 | GTPL2331 | Senicapoc (USAN) | D06640 | Q65653351 | AKOS007930800 | 4-Methyl-1H-pyrrole-2-carboxylic?acid | UNII-TS6G201A6Q | Senicapoc [USAN:INN] | Bis(4-fluorophenyl)phenylacetam | ||
| CAS number | 289656-45-7 | molecular formula | C20H15F2NO |
| molecular weight | 323.35 g/mol | Exact mass | - |
| PSA | 43.100 Ų | logp | 4.1 |
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