Hmb保护酰胺键可抑制′困难′肽的聚集，从而提高产物纯度[1-6]。保留裂解肽上Hmb基可以大大提高受保护肽片段的溶解度[7，8]和其他难处理的序列[9-11]。另外，Hmb保护的衍生物掺入与Asp或Asn残基的羧基相连的残基可抑制天冬氨酸和哌啶相关副产物的生成[12-14]。关于Hmb和假脯氨酸防止聚集效率的比较，见[15]。该产品之前的货号为04-12-1135。获取字母“A”开头的批次的分析证书 (CoA)，请选择右侧菜单中“申请批次编号以 A 开头的 CoA”的选项。 应用 Hmb protection of amide bonds has been shown to inhibit aggregation of ′difficult′ peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].The product number for this product was previously 04-12-1135..
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Fmoc-(FmocHmb)Gly-OH
CAS number：148515-84-8 molecular formula：C40H33NO8
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | Fmoc-(FmocHmb)Gly-OH, N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-glycine | ||
| CAS number | 148515-84-8 | molecular formula | C40H33NO8 |
| molecular weight | 655.700 g/mol | Exact mass | Reagent Grade |
| PSA | 112.000 Ų | logp | 7.600 |
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148515-84-8 | Fmoc-(FmocHmb)Gly-OH Novabiochem®.pdf
