Function Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b.
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Recombinant Rat MAG/Siglec-4a Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组大鼠MAG/Siglec-4a蛋白 | 重组大鼠髓鞘关联糖蛋白蛋白 | ||
| English alias | Myelin-associated Glycoprotein | GMA | sialic acid binding Ig-like lectin 4A | MAG | myelin associated glycoprotein | sialic acid-binding immunoglobulin-like lectin 4A | Siglec4a | Siglec-4a | S-MAG | 1B236 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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