一种α2糖蛋白，由一条多肽链组成，在血浆中的含量为20-55mg/100ml。它在维生素D的结合和运输中起作用，也可能在肌动蛋白稳态中发挥重要作用，因为它已被证明能以高亲和力结合单体肌动蛋白。GC球蛋白还结合循环B和T淋巴细胞的膜。临床上，严重肝病患者的浓度会降低。GC球蛋白也可能在Itai-Itai病引起的骨软化症的机制中发挥重要作用。 An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease. Product Citations: Trujillo, Glenda, David M. Habiel, Lingyin Ge, Mahalakshmi Ramadass, Nancy E. Cooke, and Richard R. Kew. "Neutrophil Recruitment to the Lung in Both C5a-and CXCL1-Induced Alveolitis Is Impaired in Vitamin D–Binding Protein-Deficient Mice." The Journal of Immunology (2013). Ge, Lingyin, Glenda Trujillo, Edmund J. Miller, and Richard R. Kew. "Circulating Complexes of the Vitamin D Binding Protein with G-Actin Induce Lung Inflammation by Targeting Endothelial Cells." Immunobiology (2013). Kilpatrick LE. Optimizing High Resolution Mass Spectrometry for the Identification of Low Abundance Post-Translational Modifications of Intact Proteins. J Proteome Res. 2017 Aug 8. doi: 10.1021/acs.jproteome.7b00244. [Epub ahead of print]. Ramadass M, Ghebrehiwet B, Kew RR. Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood. Mol Immunol. 2015 Mar;64(1):55-62. doi: 10.1016/j.molimm.2014.10.022. Epub 2014 Nov 15. Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR. Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies. J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
GC-球蛋白,人血浆,混合型(维生素D结合蛋白)
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | ≥95%(SDS-PAGE) |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
