糖化白蛋白 人

糖化人白蛋白已用于：作为用于视网膜小胶质细胞活化的无血清培养基的成分刺激永生化的近端小管上皮细胞（HK-2）产生纤连蛋白作为人视网膜微血管内皮细胞（HRMEC）培养物的培养基补充剂，以测试其对序列相似家族 18 成员 B（FAM18B）表达的影响天然存在的糖化白蛋白是糖尿病患者血糖控制的敏感指标。 应用： 白蛋白基因定位于人染色体 4q13.3。在肝脏中，它合成时是具有 609 个氨基酸的白蛋白前体。通过信号肽的切割产生具有 585 个残基的成熟白蛋白。白蛋白是血清中主要的循环蛋白。它包含三个结构域（I、II 和 III），每个结构域又细分为两个亚结构域 A 和 B。与白蛋白相关配体结合位点总共有 6 个。结构域 IIA 和 IIIA 带有小的杂环或芳香族化合物结合位点。长链脂肪酸结合位点位于 IB 和 IIIB 结构域中。 Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains. Application: Albumin, glycated human has been used: as a component of serum-free medium for retinal microglia activation to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.

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