compound introduction
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC 50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS , COX-2 , ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research Form:Solid IC50& Target:NF-κB p38 COX-2
