Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) , with IC 50 s of 37.1 and 31.8 μM for MAO-B and AChE , respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease In Vitro Ladostigil (1-10 µM) hydrochloride exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults. Ladostigil (1-10 µM) hydrochloride has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hydrochloride abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats. Ladostigil (50 μmol/kg; single p.o.) hydrochloride restores the loss of episodic memory in the object recognition test in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Pathogen-free (SPF) Sprague-Dawley ratsDosage: 17 mg/kg Administration: Oral (added to the drinking water) daily for 6 weeks Result: Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. Form:Solid IC50& Target:AChE 31.8 μM (IC 50 ) MAO-B 37.1 μM (IC 50 )
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Ladostigil hydrochloride
CAS number：209394-18-3 molecular formula：C16H21ClN2O2
overview
compound introduction
Specs
| Chinese alias | 盐酸拉多替吉 | ||
| English alias | - | ||
| CAS number | 209394-18-3 | molecular formula | C16H21ClN2O2 |
| molecular weight | 308.80 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
