DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. In Vivo DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone . After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Human leukocyte elastase (HLE)
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DMP 777
CAS number：157341-41-8(DMSO) molecular formula：C31H40N4O6
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 157341-41-8(DMSO) | molecular formula | C31H40N4O6 |
| molecular weight | 564.69 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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