Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus , is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties In Vitro Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to TolueneDosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday) Result: Reduced urinary γ-GT by 70-78%. IC50& Target:γ-glutamyl transpeptidase
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Acivicin hydrochloride
CAS number：161922-40-3(DMSO) molecular formula：C5H8Cl2N2O3
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| Chinese alias | 盐酸阿西维星 | ||
| English alias | - | ||
| CAS number | 161922-40-3(DMSO) | molecular formula | C5H8Cl2N2O3 |
| molecular weight | 215.03 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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