CV-6209 is a potent antagonist of platelet activating factor (PAF) . CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC 50 s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats In Vitro CV-6209 inhibits [ 3 H]serotonin release from rabbit platelets stimulated with PAF (30 nM). CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED 50 =0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol . CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil IC50& Target:platelet activating factor (PAF)
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CV-6209
CAS number：100488-87-7 molecular formula：C34H60ClN3O6
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| Chinese alias | - | ||
| English alias | HY-109897 | Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride | SCHEMBL9119534 | [3-[acetyl-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamoyl]oxy-2-methoxypropyl] N-octadecylcarbamate | AKOS027326457 | FT-0665237 | ||
| CAS number | 100488-87-7 | molecular formula | C34H60ClN3O6 |
| molecular weight | 642.31 g/mol | Exact mass | ≥95% |
| PSA | 98.100 Ų | logp | - |
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