LY377604 is a human β 3 -adrenergic receptor agonist with an EC 50 of 2.4 nM and also a β 1 - and β 2 - adrenergic receptor antagonist. In Vitro LY377604 is a human β 3 -adrenergic receptor agonist with an EC 50 of 2.4 nM and also a β 1 - and β 2 -adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β 1 adrenergic receptor or the human β 2 adrenergic receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 2.4 nM (human β 3 -adrenergic receptor), β 1 -adrenergic receptor, β 2 -adrenergic receptor
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LY377604
CAS number：204592-94-9 molecular formula：C31H32N4O4
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| Chinese alias | - | ||
| English alias | LY-377604 | AKOS040741992 | CHEMBL2012522 | OCC6TB3P6K | Q27285574 | DTXSID20174419 | UNII-OCC6TB3P6K | HY-13713 | SCHEMBL2920383 | 6-(4-(2-(((2S)-3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl)amino)-2-methylpropyl)phenoxy)pyridine-3-carboxamide | 204592-94-9 | | ||
| CAS number | 204592-94-9 | molecular formula | C31H32N4O4 |
| molecular weight | 524.61 g/mol | Exact mass | ≥98% |
| PSA | 122.000 Ų | logp | 5 |
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