BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels In Vivo BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats . BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t 1/2 of 11 hours and 12 hours for iv and po. And the C max is 0.97 kg/L and 0.24 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 12.5 mg/kg Administration: Oral; for 8 days Result: Showed an efficiency to reduce serum estradiol levels. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 11 hours and 12 hours for iv and po. And the C max s are 0.97 kg/L and 0.24 kg/L for iv and po. Form:Solid IC50& Target:IC50: 185 nM (hLH) and 46nM (rLH)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
BAY-899
CAS number：2471967-92-5 molecular formula：\n C25H19F2N5O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2471967-92-5 | molecular formula | \n C25H19F2N5O2 |
| molecular weight | 459.45 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
