BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor In Vivo Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MRL/lpr mice . Dosage: 1 mg/kg. Administration: Subcutaneous injection daily from 8 to 14 weeks of age. Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs. Form:Solid IC50& Target:PAD
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BB-Cl-Amidine hydrochloride
CAS number：2436747-41-8 molecular formula：C26H27Cl2N5O
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| Chinese alias | BB-Cl-脒盐酸盐 | ||
| English alias | - | ||
| CAS number | 2436747-41-8 | molecular formula | C26H27Cl2N5O |
| molecular weight | 496.43 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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