KIN101

KIN101 is a potent RNA viral inhibitor with IC 50 s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses In Vitro KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC 50 of 0.2 μM. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5. KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MRC5 cells Concentration: 10 μM Incubation Time: 24 hours Result: Caused a significant decrease in the NP protein abundance. RT-PCRCell Line: Huh7 cells Concentration: 10 μM Incubation Time: 18 hours Result: Showed a >1 log decrease in HCV RNA levels. Form:Solid IC50& Target:IC50: 2 μM (influenza virus) and >5 μM (DNV)

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