Fidarestat (SNK 860) is an inhibitor of aldose reductase , with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase , AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. In Vitro Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)
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Fidarestat
CAS number：136087-85-9(DMSO) molecular formula：C12H10FN3O4
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| Chinese alias | 非达司他 | ||
| English alias | - | ||
| CAS number | 136087-85-9(DMSO) | molecular formula | C12H10FN3O4 |
| molecular weight | 279.22 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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