PF-06843195 is a highly selective PI3Kα inhibitor with an IC 50 of 18 nM in Rat1 fibroblasts. The K i s of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy In Vitro PF-06843195 inhibits the breast cancer cell lines MCF7 and T47D proliferation with IC 50 s of 62 nM and 32 nM, respectively. PF-06843195 inhibits pAKT (T308) in MCF7 and T47D cells with IC 50 s of 7.8 nM and 8.7 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In rats, PF-06843195 can rapidly and quantitatively transform from PF-06862309 . PF-06843195 exhibits oral bioavailability (rat 25 %) following oral administration (rat 10 mg/kg) . PF-06843195 exhibits a moderate half-life (rat 3.6 h) due to high plasma clearance (30 mL/min/kg) combined with large volumes of distribution (3.0 L/kg) following intravenous administration (rat 2 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar Han Rats Dosage: 2 mg/kg (intravenous) and 10 mg/kg (oral gavage)(Pharmacokinetic Analysis) Administration: Intravenous (IV) or oral gavage (PO) Result: T 1/2 of 3.6 h for rats. Form:Solid IC50& Target:PI3Kα 18 nM (IC 50 , in Rat1 fibroblasts) PI3Kβ 360 nM (IC 50 , in Rat1 fibroblasts) PI3Kδ 160 nM (IC 50 , in Rat1 fibroblasts) PI3Kα 0.018 nM (Ki) PI3Kδ 0.28 nM (Ki)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
PF-06843195
CAS number：2067281-51-8 molecular formula：C20H25F3N8O4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 75658JDG29 | VXY | PF06843195 | PF-06843195 | HY-131972 | 1-Pyrrolidinecarboxylic acid, 3-((2'-amino-5-fluoro-2-(4-morpholinyl)(4,5'-bipyrimidin)-6-yl)amino)-3-(hydroxymethyl)-, 2,2-difluoroethyl ester, (3S)- | UNII-75658JDG29 | 2067281-51-8 | compound 1 | ||
| CAS number | 2067281-51-8 | molecular formula | C20H25F3N8O4 |
| molecular weight | 498.46 g/mol | Exact mass | ≥99% |
| PSA | 152.000 Ų | logp | 0.400 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
