SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE) . SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats In Vitro MKS 492 relaxes airway smooth muscle in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs . MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs . MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs . MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum Dosage: 3, 10 mg/kg Administration: I.v. 5 min before antigen challenge Result: Inhibited antigen-induced bron choconstriction in a dose-related manner. Form:Solid IC50& Target:type III phosphodiesterase
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
SDZ-MKS 492
CAS number：114606-56-3 molecular formula：C20H27N5O6
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 8-{[1-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]imino}-7-(2-methoxyethyl)-1,3-dimethyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione | 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-7-(2-methoxyethyl)-1,3-dimethylpurine-2,6-dione | MS-27742 | Sdz mks 492 | (8 | ||
| CAS number | 114606-56-3 | molecular formula | C20H27N5O6 |
| molecular weight | 433.46 g/mol | Exact mass | ≥98% |
| PSA | 118.000 Ų | logp | 0.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
