Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier . In Vitro Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 gDosage: 0.3 mg/kg Administration: IP; daily; for 14 days Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. Form:Solid
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Nemifitide diTFA
CAS number：204992-09-6 molecular formula：C37H45F7N10O10
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| Chinese alias | 奈米菲肽二三氟乙酸 | ||
| English alias | Nemifitide bis(trifluoroacetate) | Nemifitide ditriflutate (USAN) | 4-Fluoro-L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-arginylglycyl-L-tryptophanamide bis(trifluoroacetate) (salt) | HY-105077A | Nemifitide ditriflutate | INN00835 | INN-00835 | 27454M5E8Z | ||
| CAS number | 204992-09-6 | molecular formula | C37H45F7N10O10 |
| molecular weight | 922.80 g/mol | Exact mass | ≥99% |
| PSA | 352.000 Ų | logp | - |
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