Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation Appearance:Solid IC50& Target:Parathyroid hormone receptor 1 (PTHR1) In Vitro:Abaloparatide TFA (0-100 nM; 40 min) enhances Gs/cAMP signaling and β-arrestin recruitment in MC3T3-E1 cells. Abaloparatide TFA (0-100 nM) efficiently induces PTHR1 internalization in a dose-dependen manner with an EC 50 value of 0.8 nM in U2OS Cell In Vivo:Abaloparatide TFA (20-80 µg/kg; s.c.; daily for 30 days) enhances bone formation and cortical structure in mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague-Dawley rats Biological Activity:Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation
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Abaloparatide TFA
CAS number：unknown molecular formula：C176H301N56F3O51
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| Chinese alias | 阿巴洛帕肽 TFA | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C176H301N56F3O51 |
| molecular weight | 4074.61 g/mol | Exact mass | ≥96% |
| PSA | - | logp | - |
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