DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM. IC50& Target:IC50: 84 nM (KDM1A/LSD1) In Vitro:DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. MCE has not independently confirmed the accuracy of th In Vivo:DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is ob Biological Activity:DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM.
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DDP-38003 trihydrochloride
CAS number：unknown molecular formula：C21H29Cl3N4O
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| Chinese alias | DDP-38003 三盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H29Cl3N4O |
| molecular weight | 459.84 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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