Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D 1 receptor antagonist with a K d of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer In Vivo The metabolism of Odapipam has been studied with phenobarbital-induced rat liver microsomes. During the incubation of Odapipam, five different metabolites are formed. The electron-ionization (EI + ) mass spectra of the metabolites indicated the formation of N-desmethyl-Odapipam, 1-hydroxy-Odapipam, the two isomers of 3′-hydroxy-Odapipam and a metabolite which is dehydrogenated in the dihydrobenzofuran moiety. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Dopamine D 1 receptor
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Odapipam
CAS number：131796-63-9 molecular formula：C19H20ClNO2
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| Chinese alias | 奥达匹泮 | ||
| English alias | MS-24949 | SMR004701386 | NCGC00386542-01 | (S)-(+)-8-Chloro-5-(2,3-dihydro-benzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol | NNC 01-0756 | SCHEMBL2056522 | BCP9000991 | MLS006010322 | Odapipam | (+)-(S)-8-chloro-5-(2,3-dihydro-7-benzo | ||
| CAS number | 131796-63-9 | molecular formula | C19H20ClNO2 |
| molecular weight | 329.82 g/mol | Exact mass | ≥99% |
| PSA | 32.700 Ų | logp | 4.000 |
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