SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K i of 9.7 nM. In Vitro SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K + -currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs . In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 9.7 nM (H1 receptor)
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SUN 1334H
CAS number：607736-84-5 molecular formula：C23H28Cl2F2N2O3
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| Chinese alias | 太阳 1334H | ||
| English alias | {4-[4-[Bis-(4-fluorophenyl)methyl]piperizin-1-yl]-(E)-but-2-enyloxy}acetic Acid Dihydrochloride | AKOS040739467 | SUN 1334H | SCHEMBL5623924 | KAQMKGKFTBFMGE-SEPHDYHBSA-N | SCHEMBL1138186 | 2-[(E)-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]but-2-enoxy | ||
| CAS number | 607736-84-5 | molecular formula | C23H28Cl2F2N2O3 |
| molecular weight | 489.38 g/mol | Exact mass | - |
| PSA | 53.000 Ų | logp | - |
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