L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM. Appearance:Solid IC50& Target:Brd 126 nM (Kd) In Vitro:L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd Pf GCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A In Vivo:L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use. MCE has not independently con Biological Activity:L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
L-Moses dihydrochloride
CAS number：unknown molecular formula：C21H26Cl2N6
overview
compound introduction
Specs
| Chinese alias | L-摩西二盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H26Cl2N6 |
| molecular weight | 433.38 g/mol | Exact mass | - |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
