Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4 nM and 9.9 nM, respectively. Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal s Appearance:Solid IC50& Target:CDK6 9.9 nM (IC 50 ) CDK4 12.4 nM (IC 50 ) In Vitro:Dalpiciclib hydrochloride (0-4 μM, 72 h) inhibits cell proliferation in a dose-dependent manner. Dalpiciclib hydrochloride (0-10 μM, 6 d) inhibits the proliferation of retinoblastoma-positive tumor cell lines. MCE has not independently confirmed In Vivo:Dalpiciclib hydrochloride (oral gavage; 150mg/kg; once weekly; 3 weeks) shows antitumor activity against ESCC xenografts. Dalpiciclib hydrochloride combined with Paclitaxel (PTX) or Cisplatin (CDDP) offer synergistic inhibitory effects in ESCC xenog Biological Activity:Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4u2009nM and 9.9u2009nM, respectively . Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esop
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Dalpiciclib hydrochloride
CAS number：unknown molecular formula：C25H31ClN6O2
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| Chinese alias | 盐酸达匹昔利布 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C25H31ClN6O2 |
| molecular weight | 483.01 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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