(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP- Appearance:Solid IC50& Target:GLP-1R In Vitro:(S)-V-0219 ((S)-9) (0.1 nM) hydrochloride potentiates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 (0.1 nM) hydrochloride potentiates insulin secretion stimulated by GLP-1 in the stable human pancreatic cell line EndoC-βH1 under In Vivo:(S)-V-0219 ((S)-9) (0.04-0.2mg/kg; i.p.) hydrochloride improves glucose handling after injection of 2 g/kg glucose in normal male Wistar rats. (S)-V-0219 (0. 4mg/kg; i.g.) hydrochloride is orally active in fatty diabetic Zucker rats. (S)-V-021 Biological Activity:(S)-V-0219 hydrochloride is an enantiomer of V-0219 ( HY-143312 ). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor -1 ( GLP-1R ). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-
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(S)-V-0219 hydrochloride
CAS number：unknown molecular formula：C20H26ClF3N4O2
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| Chinese alias | (S)-V-0219 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C20H26ClF3N4O2 |
| molecular weight | 446.89 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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